Applications of the integrated smart technologies in future energy infrastructure requires the largest increase of energy utilization efficiency, which is closely dependent on our understanding of the multi-scale thermal fluid flow dynamics in virtually all fields. From space radiation science to materials in nuclear system, from circular water systems to energy related machineries, a variety of technology breakthrough depend on the understanding of the multi-scale fluid dynamics and its accurate computational prediction.  In this course, series of lectures are selected, covering computational and theoretical fluid mechanics. Technologies in circular water systems, space radiation, thermo-fluid dynamics and multi-phase flow in accelerators, heat pumps and nuclear reactors will be introduced. In addition, the applications of thermal science in energy and power system design will be discussed. Furthermore, modeling the multi-phase flow in variety scenarios of energy will be presented. The course will also cover interdisciplinary topic such as energy material science.