Frontiers in Medicine 2021 扫二维码继续学习 二维码时效为半小时

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Magnetic techniques used in surgery:

- Magnetic Compression Technique

Magnetic Compression Anastomosos (MCA) (2001) --> Magnamosis (2009)

The principle: based on the natural process of tissue remodeling and healing

A constant pressure is exerted on the apposed walls of two visceral segments by magnetic devices leading to transmural ischemia, necrosis, and healing with, finally, full-thickness anastomosis between the segments.

  • non-penetrating compression anastomosis, minimizing inflammatory reaction
  • incision-less and suture-less anastomosis
  • easily applied to minimally-invasive procedures
  • self-assembling for creation of anastomosis
  • self-adjusting according to individual tissue thickness
  • MRI inspection is limited
  • application may be limited to patients with pacemakers
  • magnetic force is difficult to be precisely controlled
  • the effects of long-term exposure to magnetic field is still largely unknown

- Magnetic Anchoring Technique

 Used in:

  • robotic surgery
  • laparascopic surgery  
  • endoscopic surgery

- Magnetic Navigation Technique

- Magnetic Levitation Technique

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Acupuncture is a technique when you insert the needle in the skin at specific acupoints on the body to prevent and treat diseases.

Maintaining Yin-Yang balance

Acupuncture stimulates blood flow triggering the activity of the body's natural painkillers-treat diseases.

How to choose points. 

​​​​​​​1) proximal-an adjacent area of ​​​​the disease.

​​​​​​​2) distal-beneath the elbows and knees, based on the distribution of meridians and collaterals.

​​​​​​​3) contralateral-acupoints located opposite to the affected area.

​​​​​​​Manipulations and Deqi.

​​​​​​​Qi (needling sensation)-reaction of meridian qi when the needle is inserted to a certain depth. directly related to the therapeutic effects. quick arrival of qi-good therapeutic effect and vice-versa.

​​​​​​​Compatibility of acupoints-method of combining points from meridians (two) exterior-interior related, method of combining left and right points, upper and lower points. Treating LBP.

​​​​​​​Based on syndrome differentiation we select acupoints. 

​​​​​​​acupoints are stimulated in the same time/

​​​​​​​

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dinara · 2021-07-30 · 默认计划 0

Acute vs Chronic.

A. Treat'Brach' in Acute condition selecting three main acupoints to relieve the pain.

2. Stress-induced, Tai Chong (liver meridians ),

 

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dinara · 2021-07-29 · 默认计划 0

Accupunture therapy on the common diseases

- Acupuncture guided by traditional chinese medicine theories to prevent and treat diseases.

- Acupuncture is used to insert needle into the skins at specific location on the body (acupoints) at various depths

- Treatment is achieved by balancing yin and yang and dredging meridians. Acupoints are seen as places where nerves, muscles and connective tissue can be stimulated. This stimulation increases blood flow while triggering the activity of the body's natural painkillers

- Accupunture technique:

1. How to choose points:

a. Selection of proximal acupoints:

- Select acupoints located on the adjacent area of disease because acupoints can be needled to treat disease around or near them.

- Means to select acupoints located in or near the affected area.

- Main acupoints: oh-yes acupoints

b. Selection of distal acupoints:

-Distal to the affected area. In this case, acupoints are located below elbows and knees. This method is based on the distribution of meridians and collaterals.

c. Selection of contralateral acupoints:

- Opposite to the affected area, known as to select acupoints on the right to treat disease on the left and vice versa.

4. Selection of acupoints according to symptoms

2. Manipulation and Deqi:

3. Acupuncture technique:

 

 
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nehl_mg · 2021-07-29 · 默认计划 0

37% bacteria, 13% vertibrates. 

 Yellowstone National park 93 degrees. Iron Mountain in California. 

10 times more bacteria cells tan human cells. 100 trillion bacteria.

A potential solution to multidrug resistance ESKAPE pathogens

E-enterococcus faecium

S-staphyloccus aureus

Find ways to defeat antibiotic resistance. 

The inner life of the cell-image with walking strange thing with ball on top of it.

In order for an object to be visible under magnification, the wavelength of the light must be no larger than the ofbject.

X-ray crystallography as a powerful technique used since 19th century. When light passes through a dense crystal of research object it creates diffraction enlarging it. How to grow a biological macromolecule Crystal. 

"Hanging-drop" vapour-diffussion.

The Discovery of penicillin was serendipity. History of this discovery.

Protein-ligand docking. Precise medicine. 

​​​​​​​Structure-based approach. Targets HIV. Viracept - drug for HIV.

​​​​​​​Aspirin.

Host-Pathogen-Environment interaction. Prof's project.

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dinara · 2021-07-26 · 默认计划 2

Anatomy of the shoulder.

rotator cuff is the initiator muscle of our shoulder movement.

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dinara · 2021-07-26 · 默认计划 0

Placenta Previa: 

a) Obstetrics and Gynecology:

- Branch of medical sciences dealing with diseases of the female reproductive system, the birth of children, and the care of women before, during, and after they give birth.

- Maternal mortality: death of women whilst pregnant or within 42 days of delivery, or termination of pregnancy, for any cause related to or aggravated by pregnancy or its management, but excluding death from incidental or accidental causes.

- Maternal mortality ratio: number of maternal death per 100,000 labors (middle and low-income countries have higher death rates of soon-to-be mothers) 

- What is the main cause of maternal mortality?

infection? obstetric hemorrhage? gestational hypertension? coagulation disorders?

- Placenta previa: 

1) DEFINITION: 

- In later pregnancy, the placenta covers up partially or completely the cervix in the lower part of the uterus lower than fetal presentation.

- Normal cases placenta must be attached to the upper area of the uterus.

2) CLINICAL FEATURES:

- Vaginal bleeding: painless and recurrent (frequent small uterine contractions lead to separation of the placenta from uterus and bleeding occurs). No pain because the uterus is not damaged and inside the pressure is not high.

- Blood pressure and heartbeat is normal

3) CLASSIFICATION:

- Based on the location of the placenta to the internal opening of the cervix, the placenta previa can be divided into 3 categories:

1. Complete/ total type: Most dangerous. The placenta covers the entire cervix

2. Partial type: placenta partially covers the cervix

3. Marginal type: edge of placenta is at the edge of the internal opening

4. Low-lying type: placenta implants in the lower uterine segment but does reach the cervical opening.

- Different types of placenta previa show different clinical features and determine different treatments.

4a) DIAGNOSIS:

- Symptoms, signs, and examination = diagnosis

- Most cases bleeding is mild and patients' vital signs are fine (normal BP and HB) however in some cases bleeding may be very serious and HB increases and BP decreases because of blood loss.

- If placenta previa is suspected an ultrasound is conducted, if B ultrasound finds the placenta covers the cervix a diagnosis can be made. Patients with placenta previa should never do a pelvic examination which can cause the separation of the placenta from the cervix and uterus. This separation may cause uterine contraction and cause vaginal bleeding and may be fatal.

- Physical examination: soft and clear-shaped uterus, no tenderness

4b) DIFFERENTIAL DIAGNOSIS:

- Distinguish a disease or condition from others that present similar signs and symptoms.

- 3 causes of antepartum bleeding:

1. Placenta abruption: painful bleeding

2. Placenta previa

3. Cervical cancer complicating pregnancy

- pathological examination and colposcope (magnifies cells of the vagina)

5) TREATMENT:

- Treatment plan based on maternal and fetal factors:

A) EXPECTANT MANAGEMENT:

1. Good: the maternal condition is ok

2. Alive: the fetal condition is ok

3. Little: mild vaginal hemorrahage 

4. Early: gestation is before 36 weeks

B) TERMINATION OF PREGNANCY:

1.  Maternal condition is unstable

2. Fetal condition is unstable

3. Massive and severe vaginal hemorrhage

4. Gestation after 36 weeks

6) RISK FACTORS:

- Rate of PP is increasing (global prevalence is 5.2% in 1000 pregnant women; higher in Asian and African studies)

1. Previous diagnosis/ history of PP, very more likely to have it in later pregnancies

2. multiple gestations/ pregnancies

3. surgery on the uterus or uterine scar

4. alcohol use and smoking

b) Retrospect:

Q1. What is the main symptom? Vaginal bleeding

Q2. When does bleeding appear? Late pregnancy (30 weeks)

Q3. What are the features of bleeding? painless and recurrent 

 

 
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nehl_mg · 2021-07-24 · 默认计划 0

placenta previa

the bleeding is painless because the the uterus is not injured and there is not pressure within the uterus.

types

complete: the placenta covers entire cervix.

partial; the placenta partially covers the cervix

marginal

low-lying

differential diagnosis; distinguishing diseases with similiar signs and symptoms.

placental abruption prensents with painful bleeding.

placenta previa presents with bleeding with no pain.

 

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benjaminiyoyo · 2021-07-22 · 默认计划 0

stomachache 循环系统

十二指肠 

直肠

回结肠

升结肠

降结肠

乙状结肠

 

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wendy85 · 2021-07-20 · 默认计划 0

Maternal mortality-the death of a woman while she is pregnant.

MM ratio-per 100 women. Evaluate the health condition of a country. 

Obstetric Hemorrhage-excessive bleeding usually during pregnancy. The main cause of maternal mortality. Gestational hypertension is high blood pressure during pregnancy. Coagulation disorders-when blood becomes thicker.

The placenta covers the entire cervix.

​​​​​​​Placenta Previa. The cervix is ​​​​the opening of the uterus. The placenta is above the cervix. In late pregnancy.

​​​​​​​Clinica features. Painless (doesn't cause significant changes in uterus pressure) and recurrent vaginal bleeding. In late pregnancy due to the uterus contractions, the placenta separates from the uterus causing bleeding.

Different types, different clinical features, different treatments.

​​​​​​​Complete type. Most severe type.

​​​​​​​Partial type

Marginal type (edge ​​​​​​to edge)

​​​​​​​Low-line (?)

​​​​​​​Diagnosis is made through ultrasound to define the place of the placenta.  To differentiate from other diseases (placental abruption-painful bleeding, placenta previa-painless bleeding, or in the worst case cervical cancer-complicating pregnancy)

Treatment. 

​​​​​​​Expectant management in the case of maternal and fetal factors is OK. (good, alive, little, early) Sex is forbidden. 

​​​​​​​Risk factors. 

​​​​​​​Multiple pregnancies, having surgery on uterus, smoking, alcohol use.

C-section because the cervix is ​​totally blocked with the placenta. 

Xiang university, the beginning

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dinara · 2021-07-20 · 默认计划 1

LIver transplantation using magnamosis (? ) tecnhique.

Laparoscopic Liver transplantation. Amazing.

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dinara · 2021-07-19 · 默认计划 0

Magnetic Compression Tecnique-Magnamosis. Based on tissue remodeling and healing. U kinda compress the middle and under the pressure exerted on the apposed walls of two visceral segments, they full-thickens.

Anastomosis is a surgical connection between two structures. Like when part of the intestine is removed left parts anatomized to each otther.

Magnetic Anchoring technique (most widely used0)

​​​​​​​Laparoscopy is the type of surgery where skin incisions are minimized. Uses robots.

Magnetic Navigation Technique Navigated by magnets (endoscopy, bronchoscopy)

Magnetic levitation technique. Artificial heart.

​​​​​​​Magnetic tracking technique. Because of too much radiation in surgery. Radiation free. No line of sight is required. 

​​​​​​​Magnetic Nanoparticles for imaging. Increase of MRI sensitivity. 

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dinara · 2021-07-19 · 默认计划 2

Magnetic surgery-surgerical treatment using utilized magnetic devices. 

- Anchoring (gallbladder through external)

-Temporary implanted (2-3 weeks)

-Permanentrly implanted. Most useful - titanium alloys. Stomach sphincter opening. First proposed and published in 2013. 

​​​​​​​Material- NdFeB. Neodiymium iron boron coated with gold or titanium nittrate (TiN).

​​​​​​​Gamma radiation is most powerfull technique for sterilization. 

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dinara · 2021-07-19 · 默认计划 0

the  disadvantage  of   magnamosis

(1)MRI   inspection  is   limited

(2)application   may  be   limited  to  patients  with   pacemakerd

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lingzhou · 2021-07-19 · 默认计划 0

Magnetic Surgery (Lv Yi, 2012)

surgical treatment by utilization of magnetic technology, including magnetic devices and carriers

advantages:

  • facilitates minimally invasive procedures

Magnetic devices used in surgery:

Intraoperatively used

  • utilized in magnetic anchoring and magnetic navigation techniques
  • meant to be removed at the end of the procedure
  • reduce the number of ports needed to adequately perform retraction, conserve triangulation, and generate surgical area in a safe and efficient way
  • example: magnetic anchoring devices for laparoscopic surgery (eg. Levita Magnetic Surgical System)

Temporarily planted

  • utilized in magnetic compression anastomoses of hollow viscera such as digestive tract (eg. small intestine), as well as in vascular anastomoses
  • meant to work over a period of time after the surgical procedure has ended (eg. 2-3 weeks)
  • titanium nitride coating is recommended (is stable in the body for at least 500 hours)

Permanently implanted

  • meant to remain intracorporeal for the life of the patient
  • example: magnetic sphincter augmentation for gastroesophagal reflux disease (disfunction of the cardiac sphincter of the stomach) and magnetic hyoid suspension for sleep apnea (the patient's airways collapse during sleep)
  • titanium alloy sealing by laser is recommended

Magnetic materials used in surgery:

Neodymium iron boron (NdFeB) - the most powerful magnetic material on Earth

  • guarantees adequate magnetic force
  • can be paired with magnetizable materials
  • is a corrosive substance and has poor stability
  • will release harmful ions during corrosion

Solution: Surface coatings and layers:

  • ensure biocompatibility
  • prevent leaking of toxic components into tissue

eg. polycarbonate, gold, parolene (in multiple layers for redundancy)

Sterilization Methods:

should not cause corrosion and degradation of magnetic properties

  • corrosive sterilization
  • high temperature sterilization 
  • ethylene oxide sterilization
  • low temperature cold plasma techniques
  • gamma radiation sterilization

 

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